Prepare your margarita glasses. Combine chili powder and sea salt in a small saucer. Rim the outside of your glass(es) with lime, taking care to only wet the outside. Dip rimmed glass(es) upright in chili powder and sea salt mixture and set aside.
Combine all margarita ingredients in a blender, and blend until smooth. Taste and adjust agave and/or alcohol quantities, if desired.
Add 1 cup of ice to blender, blending again until smooth.
Fill rimmed margarita glasses with margarita mixture. Garnish with a lime wheel, if desired, and enjoy.